Article
The HIV-1 repeated sequence R as a robust hot-spot for copy-choice recombination
15 Sept 2001
Abstract excerpt
Template switching during reverse transcription is crucial for retroviral replication. While strand transfer on the terminal repeated sequence R is essential to achieve reverse transcription, template switching from internal regions of the genome (copy choice) leads to genetic recombination. We have developed an experimental system to study copy-choice recombination in vitro along the HIV-1 genome. We identify...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
