Article
Factors regulating template switch <i>in vitro</i> by viral RNA-dependent RNA polymerases: Implications for RNA–RNA recombination
17 Apr 2001
Abstract excerpt
Copy-choice RNA recombination occurs during viral RNA synthesis when the viral transcription complex switches templates. We demonstrate that RNA-dependent RNA polymerase from bovine viral diarrhea virus and the replicases from three plant-infecting RNA viruses can produce easily detectable recombination products in vitro by switching templates during elongative RNA synthesis. Template sequence and/or structure,...
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