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Article

Template switching in DNA replication can create and maintain RNA hairpins.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2022

Mönttinen Heli A M, Löytynoja Ari

Abstract excerpt

The evolutionary origin of RNA stem structures and the preservation of their base pairing under a spontaneous and random mutation process have puzzled theoretical evolutionary biologists. DNA replication-related template switching is a mutation mechanism that creates reverse-complement copies of sequence regions within a genome by replicating briefly along either the complementary or nascent DNA strand. Depending...

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Identifiers

PMID: 35046021
DOI: 10.1073/pnas.2107005119
PMCID: PMC8794818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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