Article
Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription.
RNA (New York, N.Y.) - 1 Aug 2001
Berkhout B, Vastenhouw N L, Klasens B I, Huthoff H
Abstract excerpt
Two obligatory DNA strand transfers take place during reverse transcription of a retroviral RNA genome. The first strand transfer is facilitated by terminal repeat (R) elements in the viral genome. This strand-transfer reaction depends on base pairing between the cDNA of the 5'R and the 3'R. There is accumulating evidence that retroviral R regions contain features other than sequence complementarity that...
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