Article
A promoter polymorphism -945C>G in the connective tissue growth factor in heart failure patients with mechanical circulatory support: a new marker for bridge to recovery?
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery - 1 Jan 2015
Posch Maximilian G, Schmidt Gunther, Steinhoff Laura, Perrot Andreas, Drews Thorsten, Dandel Michael, Krabatsch Thomas, Hetzer Roland, Potapov Evgenij V
Abstract excerpt
OBJECTIVES: Mechanical circulatory support (MCS) creates improvement of cardiac function in a small portion of patients with idiopathic dilated cardiomyopathy (iDCM). Among other factors, cardiomyocyte hypertrophy seems to represent an important prerequisite for MCS-related cardiac recovery. We have previously shown that connective tissue growth factor (CTGF) leads to adaptive cardiomyocyte hypertrophy associated...
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