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Article

Role of Repeat I in the fast inactivation kinetics of the Ca(V)2.3 channel.

Biochimica et biophysica acta - 1 Oct 2001

Bernatchez G, Berrou L, Benakezouh Z, Ducay J, Parent L

Abstract excerpt

The molecular basis for inactivation in Ca(V)2.3 (alpha 1E) channels was studied after expression of alpha 1E/alpha 1C (Ca(V)2.3/Ca(V)1.2) chimeras in Xenopus oocytes. In the presence of 10 mM Ba(2+), the CEEE chimera (Repeat I+part of the I-II linker from Ca(V)1.2) displayed inactivation properties similar to Ca(V)1.2 despite being more than 90% homologous to Ca(V)2.3. The transmembrane segments of Repeat I did...

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Identifiers

PMID: 11557022
DOI: 10.1016/s0005-2736(01)00373-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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