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Article

A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis.

The Journal of clinical investigation - 1 Aug 2001

Haase I, Hobbs R M, Romero M R, Broad S, Watt F M

Abstract excerpt

In normal epidermis, beta1 integrin expression is confined to the basal layer, whereas in hyperproliferative epidermis, integrins are also expressed in the suprabasal layers. Transgenic mice in which integrins are expressed suprabasally via the involucrin promoter have a sporadic psoriatic phenotype; however, the mechanism by which integrins contribute to the pathogenesis of psoriasis is unknown. We observed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11518726
DOI: 10.1172/JCI12153
PMCID: PMC209397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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