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Article

Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects.

Cell death and differentiation - 1 Jul 2021

Bowen Margot E, Mulligan Abigail S, Sorayya Aryo, Attardi Laura D

Abstract excerpt

Inappropriate activation of the p53 transcription factor is thought to contribute to the developmental phenotypes in a range of genetic syndromes. Whether p53 activation drives these developmental phenotypes by triggering apoptosis, cell cycle arrest, or other p53 cellular responses, however, has remained elusive. As p53 hyperactivation in embryonic neural crest cells (NCCs) drives a number of phenotypes,...

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Identifiers

PMID: 33574585
DOI: 10.1038/s41418-021-00738-7
PMCID: PMC8257737

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