Article
Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death.
Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2000
Roth K A, Kuan C, Haydar T F, D'Sa-Eipper C, Shindler K S, Zheng T S, Kuida K, Flavell R A, Rakic P
Abstract excerpt
The number of neurons in the mammalian brain is determined by a balance between cell proliferation and programmed cell death. Recent studies indicated that Bcl-X(L) prevents, whereas Caspase-3 mediates, cell death in the developing nervous system, but whether Bcl-X(L) directly blocks the apoptotic function of Caspase-3 in vivo is not known. To examine this question, we generated bcl-x/caspase-3 double mutants and...
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