Article
Wnt7b regulates placental development in mice.
Developmental biology - 15 Sept 2001
Parr B A, Cornish V A, Cybulsky M I, McMahon A P
Abstract excerpt
Secreted Wnt proteins regulate many developmental processes in multicellular organisms. We have generated a targeted mutation in the mouse Wnt7b gene. Homozygous Wnt7b mutant mice die at midgestation stages as a result of placental abnormalities. Wnt7b expression in the chorion is required for fusion of the chorion and allantois during placental development. The alpha4 integrin protein, required for...
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