Article
Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2010
Fotaki Vassiliki, Larralde Osmany, Zeng Shaoju, McLaughlin David, Nichols Jennifer, Price David J, Theil Thomas, Mason John O
Abstract excerpt
Wnt signalling proteins regulate many aspects of animal development. We have investigated the function of mouse Wnt8b during forebrain development. Wnt8b is expressed in a highly restricted pattern including the prospective hippocampus and hypothalamus. Mutant mice lacking Wnt8b are viable and healthy. The size and morphology of the hippocampus appeared normal in mutant embryos and adults, and we found no...
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