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Article

WNT-5A: signaling and functions in health and disease

29 Oct 2015

Abstract excerpt

WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present extensive structural malformations. WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration,...

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PMID: 26514730
DOI: 10.1007/s00018-015-2076-y

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