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The role of imprinting genes’ loss of imprints in cancers and their clinical implications

15 May 2024

Abstract excerpt

Genomic imprinting plays an important role in the growth and development of mammals. When the original imprint status of these genes is lost, known as loss of imprinting (LOI), it may affect growth, neurocognitive development, metabolism, and even tumor susceptibility. The LOI of imprint genes has gradually been found not only as an early event in tumorigenesis, but also to be involved in progression. More than...

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Share to Epigenetics and DNA Methylation
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PMID: 38812777
DOI: 10.3389/fonc.2024.1365474

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