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Article

Multipoint imprinting analysis in sporadic colorectal cancers with and without microsatellite instability.

International journal of oncology - 1 Aug 2000

Nishihara S, Hayashida T, Mitsuya K, Schulz T C, Ikeguchi M, Kaibara N, Oshimura M

Abstract excerpt

Disrupted imprinting is implicated in certain tumorigenesis. Since aberrant methylation has been described for a majority of microsatellite instability (MSI)-positive sporadic colorectal cancers, we have investigated alteration to the imprinting in 55 sporadic colorectal cancers with or without MSI. Loss of imprinting (LOI) of IGF2 and PEG1/MEST was observed in 42% and 35% of informative cancers, respectively....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10891541
DOI: 10.3892/ijo.17.2.317

Genes

IGF2
MEST
NDN
SNRPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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