Article
Platelet-associated anti-GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb.
Blood - 15 Sept 2001
Kosugi S, Tomiyama Y, Honda S, Kato H, Kiyoi T, Kashiwagi H, Kurata Y, Matsuzawa Y
Abstract excerpt
Localization of epitopes for platelet-associated (PA) anti-GPIIb-IIIa (alpha(IIb)beta(3)) autoantibodies in chronic immune thrombocytopenic purpura remains elusive. Previous studies suggest that PA antibodies recognize the tertiary structure of intact glycoprotein (GP) IIb-IIIa. To localize their epitopes using antigen-capture enzyme-linked immunosorbent assay (ELISA), the reactivity of 34 PA anti-GPIIb-IIIa...
Topics
- Adult
- Aged
- Antibodies, Monoclonal
- Autoantibodies
- Autoantigens
- Binding Sites
- Blood Platelets
- Cell Line
- Chronic Disease
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Female
- Fibrinogen
- Humans