Article
Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies.
Blood - 15 Nov 1990
Ginsberg M H, Frelinger A L, Lam S C, Forsyth J, McMillan R, Plow E F, Shattil S J
Abstract excerpt
Normal primary platelet aggregation requires agonist-mediated activation of membrane GPIIb-IIIa, binding of fibrinogen to GPIIb-IIIa, and cellular events after ligand binding. PAC1 monoclonal antibody distinguishes between resting and activated states of GPIIb-IIIa, and other antibodies preferentially recognize GPIIb (PMI-1) or IIIa (anti-LIBS1) after the binding of fibrinogen or fibrinogen-mimetic peptides, such...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.