Article
Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies.
Blood - 15 Nov 1990
Ginsberg M H, Frelinger A L, Lam S C, Forsyth J, McMillan R, Plow E F, Shattil S J
Abstract excerpt
Normal primary platelet aggregation requires agonist-mediated activation of membrane GPIIb-IIIa, binding of fibrinogen to GPIIb-IIIa, and cellular events after ligand binding. PAC1 monoclonal antibody distinguishes between resting and activated states of GPIIb-IIIa, and other antibodies preferent...
Topics
- Antibodies, Monoclonal
- Blood Coagulation Disorders
- Blood Platelets
- Cell Membrane
- Female
- Flow Cytometry
- Genetic Variation
- Humans
- Ligands
- Middle Aged
- Platelet Aggregation
- Platelet Membrane Glycoproteins
- Primary Myelofibrosis
- Thrombasthenia