Article
Adhesive and signaling properties of a naturally occurring allele of glycoprotein IIIa with an amino acid substitution within the ligand binding domain-the Pena/Penb platelet alloantigenic epitopes.
Blood - 1 Nov 1998
Wang R, Newman P J
Abstract excerpt
Platelet membrane glycoprotein IIIa (GPIIIa) is the most polymorphic integrin subunit in man, with at least seven recognized allelic isoforms present in the human gene pool. Whether these allelic variants of the GPIIb-IIIa complex differ in the ability to interact with the adhesive ligand fibrino...
Topics
- Alleles
- Amino Acid Substitution
- Animals
- Antigens, Human Platelet
- Binding Sites
- CHO Cells
- Cell Adhesion
- Cell Adhesion Molecules
- Cricetinae
- Cricetulus
- Fibrinogen
- Focal Adhesion Kinase 1
- Focal Adhesion Protein-Tyrosine Kinases
- Humans
- Ligands
- Oligopeptides
- Platelet Glycoprotein GPIIb-IIIa Complex
- Protein Conformation