Article
Identification of a novel 14-3-3zeta binding site within the cytoplasmic domain of platelet glycoprotein Ibalpha that plays a key role in regulating the von Willebrand factor binding function of glycoprotein Ib-IX.
Circulation research - 4 Dec 2009
Yuan Yanhong, Zhang Weilin, Yan Rong, Liao Yi, Zhao Lili, Ruan Changgeng, Du Xiaoping, Dai Kesheng
Abstract excerpt
RATIONALE: The interaction between platelet glycoprotein (GP) Ib-IX and von Willebrand factor (VWF) is initiated by conformational changes in immobilized VWF and is also regulated by the intraplatelet proteins 14-3-3zeta and filamin A. Both 14-3-3zeta and filamin A associate with the cytoplasmic domain of GPIbalpha, whereas little is known about their relationship in regulating the VWF binding function of...
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