Article
A two-amino acid insertion in the Cys146- Cys167 loop of the alphaIIb subunit is associated with a variant of Glanzmann thrombasthenia. Critical role of Asp163 in ligand binding.
The Journal of clinical investigation - 15 Sept 1998
Honda S, Tomiyama Y, Shiraga M, Tadokoro S, Takamatsu J, Saito H, Kurata Y, Matsuzawa Y
Abstract excerpt
The ligand binding site(s) of the alpha subunit of integrin alphaIIb beta3 (GPIIb-IIIa), a prototypic non-I domain integrin, remains elusive. In this study, we have characterized a Japanese variant of Glanzmann thrombasthenia, KO, whose platelets express normal amounts of alphaIIb beta3. KO plate...
Topics
- Adult
- Binding Sites
- Female
- Humans
- Integrins
- Ligands
- Molecular Sequence Data
- Mutation
- Platelet Glycoprotein GPIIb-IIIa Complex
- Protein Conformation
- RNA, Messenger