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Article

Design of a single protein that spans the entire 2-V range of physiological redox potentials.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jan 2016

Hosseinzadeh Parisa, Marshall Nicholas M, Chacón Kelly N, Yu Yang, Nilges Mark J, New Siu Yee, Tashkov Stoyan A, Blackburn Ninian J, Lu Yi

Abstract excerpt

The reduction potential (E°') is a critical parameter in determining the efficiency of most biological and chemical reactions. Biology employs three classes of metalloproteins to cover the majority of the 2-V range of physiological E°'s. An ultimate test of our understanding of E°' is to find out the minimal number of proteins and their variants that can cover this entire range and the structural features...

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PMID: 26631748
DOI: 10.1073/pnas.1515897112
PMCID: PMC4720346

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