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Article

Control of Allosteric Protein Electrochemical Switches with Biomolecular and Electronic Signals.

The journal of physical chemistry letters - 16 Jul 2020

Bollella Paolo, Edwardraja Selvakumar, Guo Zhong, Kirill Alexandrov, Katz Evgeny

Abstract excerpt

The construction of allosteric protein switches is a key goal of synthetic biology. Such switches can be compiled into signaling systems mimicking information and energy processing systems of living organisms. Here we demonstrate construction of a biocatalytic electrode functionalized with a recombinant chimeric protein between pyrroloquinoline quinone-dependent glucose dehydrogenase and calmodulin. This...

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PMID: 32602718
DOI: 10.1021/acs.jpclett.0c01223

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