Article
Unannotated single nucleotide polymorphisms in the TATA box of erythropoiesis genes show in vitro positive involvements in cognitive and mental disorders.
BMC medical genetics - 22 Oct 2020
Ponomarenko Mikhail, Sharypova Ekaterina, Drachkova Irina, Chadaeva Irina, Arkova Olga, Podkolodnaya Olga, Ponomarenko Petr, Kolchanov Nikolay, Savinkova Ludmila
Abstract excerpt
BACKGROUND: Hemoglobin is a tetramer consisting of two α-chains and two β-chains of globin. Hereditary aberrations in the synthesis of one of the globin chains are at the root of thalassemia, one of the most prevalent monogenic diseases worldwide. In humans, in addition to α- and β-globins, embryonic zeta-globin and fetal γ-globin are expressed. Immediately after birth, the expression of fetal Aγ- and Gγ-globin...
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