Article
Probing the receptor recognition site of the FimH adhesin by fimbriae-displayed FimH-FocH hybrids.
Microbiology (Reading, England) - 1 Jul 1998
Knudsen Thomas B, Klemm Per
Abstract excerpt
Type 1 fimbriae are surface organelles of Escherichia coli which mediate D-mannose-sensitive binding to different host surfaces. This binding is conferred by the minor fimbrial component FimH. The binding domain of the FimH adhesin has been studied by constructing hybrids of FimH and a homologous...
Topics
- Adhesins, Escherichia coli
- Agglutination
- Amino Acid Sequence
- Animals
- Cells, Cultured
- Cloning, Molecular
- Erythrocytes
- Escherichia coli
- Fimbriae, Bacterial
- Guinea Pigs
- Mannosides
- Molecular Sequence Data
- Phenotype
- Recombinant Fusion Proteins
- Recombination, Genetic
- Sequence Homology, Amino Acid
- Yeasts