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Inhibition profiles of mono- and polyvalent FimH antagonists against 10 different Escherichia coli strains

1 Jan 2015

Abstract excerpt

Mono- and polyvalent ligands with strong affinities for the mannose-binding adhesin FimH were synthesised, and their anti-adhesive properties against ten E. coli strains were compared in two cell-based assays. The compounds were assessed against the non-pathogenic E. coli K12 and nine strains isolated by coproculture or from patients with osteoarticular infections (OIs), Crohn's disease (CD) and urinary tract...

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PMID: 26440382
DOI: 10.1039/c5ob01581b

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