Article
Microsatellite instability occurs in defined subsets of patients with acute myeloblastic leukaemia.
British journal of haematology - 1 Aug 2001
Das-Gupta E P, Seedhouse C H, Russell N H
Abstract excerpt
Using a sensitive fluorescent-polymerase chain reaction technique we looked for microsatellite instability (MSI) as functional evidence of mismatch repair defects in 71 cases of acute myeloblastic leukaemia (AML). MSI was assessed at 11 loci in matched leukaemic and constitutional DNA. Nine out of 71 patients (13%) were found to have MSI. Four of these patients had therapy-related leukaemia and the remaining five...
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