Article
Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies.
Haematologica - 1 Sept 2013
Gaymes Terry J, Mohamedali Azim M, Patterson Miranda, Matto Nazia, Smith Alexander, Kulasekararaj Austin, Chelliah Rajani, Curtin Nicola, Farzaneh Farzin, Shall Sydney, Mufti Ghulam J
Abstract excerpt
Inactivation of the DNA mismatch repair pathway manifests as microsatellite instability, an accumulation of mutations that drives carcinogenesis. Here, we determined whether microsatellite instability in acute myeloid leukemia and myelodysplastic syndrome correlated with chromosomal instability and poly (ADP-ribose) polymerase (PARP) inhibitor sensitivity through disruption of DNA repair function. Acute myeloid...
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