Article
Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors.
International journal of radiation biology - 1 Jun 2001
Nakanishi M, Tanaka K, Takahashi T, Kyo T, Dohy H, Fujiwara M, Kamada N
Abstract excerpt
PURPOSE: Genetic alterations, including microsatellite instability (MSI), are ultimate steps toward malignant process. To investigate MSI in A-bomb survivors, leukaemic cells were analysed from 13 acute myelocytic leukaemia patients with a history of radiation exposure and also in 12 de novo patients. MATERIALS AND METHODS: To assess the microsatellite changes, a fluorescent system in 10 loci (BAT40, D3S643,...
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