Article
Repeated sequences in CASPASE-5 and FANCD2 but not NF1 are targets for mutation in microsatellite-unstable acute leukemia/myelodysplastic syndrome.
Molecular cancer research : MCR - 1 May 2005
Offman Judith, Gascoigne Karen, Bristow Fiona, Macpherson Peter, Bignami Margherita, Casorelli Ida, Leone Giuseppe, Pagano Livio, Sica Simona, Halil Ozay, Cummins David, Banner Nicholas R, Karran Peter
Abstract excerpt
Microsatellite instability (MSI) in tumors is diagnostic for inactive DNA mismatch repair. It is widespread among some tumor types, such as colorectal or endometrial carcinoma, but is rarely found in leukemia. Therapy-related acute myeloid leukemia/myelodysplastic syndrome (tAML/MDS) is an exception, and MSI is frequent in tAML/MDS following cancer chemotherapy or organ transplantation. The development of MSI+...
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