Article
Replication errors in hematological neoplasias: genomic instability in progression of disease is different among different types of leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 1996
Ohyashiki J H, Ohyashiki K, Aizawa S, Kawakubo K, Shimamoto T, Iwama H, Hayashi S, Toyama K
Abstract excerpt
Genetic alteration, including genomic instability, is an ultimate step toward the malignant process. One approach to delineating replication errors in cancer cells is to determine the alterations of microsatellites, which are short, repeated nucleotide sequences existing throughout the genomes. W...
Topics
- DNA Replication
- DNA, Neoplasm
- Disease Progression
- Fluorescence
- Hematologic Neoplasms
- Humans
- Leukemia
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid, Acute
- Loss of Heterozygosity
- Microsatellite Repeats
- Mutation
- Myelodysplastic Syndromes
- Polymerase Chain Reaction