Article
The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis.
Genes and immunity - 1 Aug 2001
Dai K Z, Harbo H F, Celius E G, Oturai A, Sørensen P S, Ryder L P, Datta P, Svejgaard A, Hillert J, Fredrikson S, Sandberg-Wollheim M, Laaksonen M, Myhr K M, Nyland H, Vartdal F, Spurkland A
Abstract excerpt
The T cell specific adapter protein (TSAd) encoded by the SH2D2A gene is involved in the control of T cell activation. The gene is located in the 1q21 region, which has been implicated in susceptibility to experimental allergic encephalomyelitis in the mouse. We therefore evaluated whether a polymorphic GA repeat (GA(13)-GA(33)) within the promoter region of the SH2D2A gene shows association to multiple sclerosis...
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