Article
Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene.
Genes and immunity - 1 Jun 2004
Smerdel A, Dai K-Z, Lorentzen A R, Flatø B, Maslinski S, Thorsby E, Førre Ø, Spurkland A
Abstract excerpt
T-cell-specific adapter protein (TSAd) involved in the negative control of T-cell activation is encoded by the SH2D2A gene. Our recent studies indicate that homozygosity for short (ie GA(13) and GA(16)) alleles of the SH2D2A gene promoter is associated with development of multiple sclerosis. To study whether the same SH2D2A promoter polymorphism also contributes to the genetic susceptibility to develop juvenile...
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