Article
The SH2D2A gene and susceptibility to multiple sclerosis.
Journal of neuroimmunology - 15 Jul 2008
Lorentzen Aslaug R, Smestad Cathrine, Lie Benedicte A, Oturai Annette B, Akesson Eva, Saarela Janna, Myhr Kjell-Morten, Vartdal Frode, Celius Elisabeth G, Sørensen Per S, Hillert Jan, Spurkland Anne, Harbo Hanne F
Abstract excerpt
We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA(16)-rs926103()A haplotype was associated with MS in Norwegians (OR 1.4, P=0.04). A similar...
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