Article
Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells.
Oncogene - 23 Aug 2001
Sayan A E, Sayan B S, Findikli N, Ozturk M
Abstract excerpt
p53 and p73 proteins activate similar target genes and induce apoptosis and cell cycle arrest. However, p53, but not p73 is considered a tumour-suppressor gene. Unlike p53, p73 deficiency in mice does not lead to a cancer-prone phenotype, and p73 gene is not mutated in human cancers, including he...
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