Article
Inactivation of retinoblastoma (RB) tumor suppressor by oncogenic isoforms of the p53 family member p73.
The Journal of biological chemistry - 18 Apr 2003
Stiewe Thorsten, Stanelle Jens, Theseling Carmen C, Pollmeier Barbara, Beitzinger Michaela, Pützer Brigitte M
Abstract excerpt
The p53 family includes three members that share significant sequence homology, yet exhibit fundamentally different functions in tumorigenesis. Whereas p53 displays all characteristics of a classical tumor suppressor, its homologues p63 and p73 do not. We have previously shown, that NH(2)-terminally truncated isoforms of p73 (Delta TA-p73), which act as dominant-negative inhibitors of p53 are frequently...
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