Article
Identification of two susceptibility loci for vascular fragility in the Brown Norway rat.
Physiological genomics - 28 Aug 2001
Harris E L, Stoll M, Jones G T, Granados M A, Porteous W K, Van Rij A M, Jacob H J
Abstract excerpt
A trait of vascular fragility, characterized by the formation of abrupt defects within the elastic laminae of the abdominal aorta, has been identified in Brown Norway (BN) rats. These lesions are greatly exacerbated in F(1) rats from a BN x New Zealand genetically hypertensive (GH) intercross, implying that the genetic background provided by the GH rat influences lesion severity. The F(2) progeny of the BN x GH...
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