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Article

Protease inhibitor 15, a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat.

Physiological genomics - 15 Jun 2014

Falak Samreen, Schafer Sebastian, Baud Amelie, Hummel Oliver, Schulz Herbert, Gauguier Dominique, Hubner Norbert, Osborne-Pellegrin Mary

Abstract excerpt

The inbred Brown Norway (BN) rat develops spontaneous ruptures of the internal elastic lamina (RIEL) of the abdominal aorta (AA) and iliac arteries. Prior studies with crosses of the BN/Orl RJ (susceptible) and LOU/M (resistant) showed the presence of a significant QTL on chromosome 5 and the production of congenic rats proved the involvement of this locus. In this study, we further dissected the above-mentioned...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24790086
DOI: 10.1152/physiolgenomics.00004.2014
PMCID: PMC4060037

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