Article
Genetic mapping and characterization of the bleeding disorder in the fawn-hooded hypertensive rat.
Thrombosis and haemostasis - 1 Jun 2003
Datta Yvonne H, Wu Francisca C, Dumas Pierre C, Rangel-Filho Artur, Datta Milton W, Ning Gang, Cooley Brian C, Majewski Rebecca R, Provoost Abraham P, Jacob Howard J
Abstract excerpt
Release of platelet dense granule contents occurs in response to vascular injury, playing an important role in platelet aggregation and primary hemostasis. Abnormalities of the platelet dense granules results in a bleeding disorder of variable severity termed "storage pool defect" (SPD). We have examined the fawn-hooded hypertensive (FHH) rat as a model of SPD in order to genetically map the locus (Bd)...
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