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Article

BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions.

The Journal of biological chemistry - 2 Nov 2001

Brzovic P S, Meza J E, King M C, Klevit R E

Abstract excerpt

Cancer-predisposing missense mutations in the RING domain of BRCA1 primarily target Zn(2+)-liganding residues. Here we report on the structural consequences of such mutations introduced into the second Zn(2+) site (Site II) of the BRCA1 RING domain and their effect on the interaction with the BARD1 RING domain. Each of the BRCA1 Site II mutants still interact and form a stable heterodimer with BARD1. Limited...

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Share to BRCA1 Protein
Share to Dimerization
Share to Hydrolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Protein Conformation

Share to Spectrometry, Mass, Electrospray Ionization

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 11526114
DOI: 10.1074/jbc.M106551200

Genes

BRCA1
BARD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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