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Article

The cancer-predisposing mutation C61G disrupts homodimer formation in the NH2-terminal BRCA1 RING finger domain.

The Journal of biological chemistry - 3 Apr 1998

Brzovic P S, Meza J, King M C, Klevit R E

Abstract excerpt

The breast and ovarian cancer tumor suppressor gene, BRCA1, encodes for a Zn2+-binding RING finger motif located near the protein NH2 terminus. The RING finger motif is characterized by eight conserved Cys and His residues which form two Zn2+-binding sites termed Site I and Site II. We used limit...

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BRCA1 Protein
Breast Neoplasms
Dimerization
BRCA1 gene
Genes, Tumor Suppressor
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

Sequence Analysis

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Identifiers

PMID: 9525870
DOI: 10.1074/jbc.273.14.7795

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9525870-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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The cancer-predisposing mutation C61G disrupts homodimer formation in the NH2-terminal BRCA1 RING finger domain.PMID 9525870Read ↗

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