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Article

Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers.

Human molecular genetics - 1 Feb 1998

Thai T H, Du F, Tsan J T, Jin Y, Phung A, Spillman M A, Massa H F, Muller C Y, Ashfaq R, Mathis J M, Miller D S, Trask B J, Baer R, Bowcock A M

Abstract excerpt

Germline alterations of BRCA1 result in susceptibility to breast and ovarian cancer. The protein encoded by BRCA1 interacts in vivo with the BRCA1-associated RING domain (BARD1) protein. Accordingly, BARD1 is likely to be a critical factor in BRCA1-mediated tumor suppression and may also serve as a target for tumorigenic lesions in some human cancers. We have now determined the genomic structure of BARD1 and...

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Source

Identifiers

PMID: 9425226
DOI: 10.1093/hmg/7.2.195

Genes

BARD1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers.PMID 9425226Read ↗

Identification and characterization of missense alterations in the BRCA1 associated RING domain (<i>BARD1</i>) gene in breast and ovarian cancerSemantic proximity Read ↗

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Cancer predisposing BARD1 mutations in breast-ovarian cancer families.Semantic proximity Read ↗

BARD1 mystery: tumor suppressors are cancer susceptibility genesSemantic proximity Read ↗

The Effects of Genetic and Epigenetic Alterations of BARD1 on the Development of Non-Breast and Non-Gynecological Cancers.Semantic proximity Read ↗

Cancer predisposing BARD1 mutations affect exon skipping and are associated with overexpression of specific BARD1 isoforms.Semantic proximity Read ↗

Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility: a case-control analysis.Semantic proximity Read ↗

Frequent incidence of BARD1-truncating mutations in germline DNA from triple-negative breast cancer patients.Semantic proximity Read ↗

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BARD1 Pathogenic Variants are Associated with Triple-Negative Breast Cancer in a Spanish Hereditary Breast and Ovarian Cancer Cohort.Semantic proximity Read ↗

Summary of BARD1 Mutations and Precise Estimation of Breast and Ovarian Cancer Risks Associated with the Mutations.Semantic proximity Read ↗

Nordic collaborative study of the BARD1 Cys557Ser allele in 3956 patients with cancer: enrichment in familial BRCA1/BRCA2 mutation-negative breast cancer but not in other malignancies.Semantic proximity Read ↗

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