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Article

Identification of residues required for the interaction of BARD1 with BRCA1.

The Journal of biological chemistry - 15 Mar 2002

Morris Joanna R, Keep Nicholas H, Solomon Ellen

Abstract excerpt

The breast and ovarian cancer predisposition gene product BRCA1, binds to BARD1 at its N terminus. In cells BRCA1 is found as a heterodimer with BARD1 and may represent the functionally active form of BRCA1. Using yeast two-hybrid and split-hybrid screens we have identified 16 independent missense mutations which prevent the ability of the BARD1 N terminus to heterodimerize with BRCA1. With reference to the...

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Source

Identifiers

PMID: 11773071
DOI: 10.1074/jbc.M109249200

Genes

BRCA1
BARD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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