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Article

Identification and characterization of missense alterations in the BRCA1 associated RING domain (<i>BARD1</i>) gene in breast and ovarian cancer

1 Aug 2005

Abstract excerpt

BACKGROUND: BRCA1 associated RING domain protein (BARD1) was originally identified due to its interaction with the RING domain of BRCA1. BARD1 is required for S phase progression, contact inhibition and normal nuclear division, as well as for BRCA1 independent, p53 dependent apoptosis. METHODS: To investigate whether alterations in BARD1 are involved in human breast and ovarian cancer, we used single strand...

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Identifiers

PMID: 16061562
DOI: 10.1136/jmg.2004.030049

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