Article
Clonal composition of human adamantinomatous craniopharyngiomas and somatic mutation analyses of the patched (PTCH), Gsalpha and Gi2alpha genes.
Neuroscience letters - 7 Sept 2001
Sarubi J C, Bei H, Adams E F, Boson W L, Friedman E, Brandão K, Kalapothakis E, Miranda D, Valle F L, Sarquis M S, De Marco L
Abstract excerpt
Craniopharyngioma is the most common childhood tumor and thought to arise from embryonic remnants of Rathke's pouch. The paucity of published data on the molecular basis of these tumors prompted us to examine 22 adamantinomatous craniopharyngiomas looking for genetic abnormalities. Using the X-linked polymorphic androgen receptor gene as a tool for X-chromosome inactivating analysis, we found that a subset of...
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