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Article

Sonic Hedgehog pathway is upregulated in adamantinomatous craniopharyngiomas.

European journal of endocrinology - 1 May 2015

Gomes D C, Jamra S A, Leal L F, Colli L M, Campanini M L, Oliveira R S, Martinelli C E, Elias P C L, Moreira A C, Machado H R, Saggioro F, Neder L, Castro M, Antonini S R

Abstract excerpt

OBJECTIVES: Pituitary stem cells play a role in the oncogenesis of human adamantinomatous craniopharyngiomas (aCPs). We hypothesized that crosstalk between the Wnt/β-catenin and Sonic Hedgehog (SHH) pathways, both of which are important in normal pituitary development, would contribute to the pathogenesis of aCPs. DESIGN: To explore the mRNA and protein expression of components of the SHH signaling pathway in...

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Source

Identifiers

PMID: 25693592
DOI: 10.1530/EJE-14-0934

Genes

SHH
GLI1
GLI3
SMO
SUFU
CTNNB1
GLI2
PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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