Article
CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas.
Hormones & cancer - 1 Aug 2010
Campanini Marina Lanciotti, Colli Leandro Machado, Paixao Beatriz Maria Carvalho, Cabral Tatiana Pereira Freitas, Amaral Fernando Colbari, Machado Helio Rubens, Neder Luciano Serafin, Saggioro Fabiano, Moreira Ayrton Custodio, Antonini Sonir Roberto Rauber, de Castro Margaret
Abstract excerpt
Genes involved in formation/development of the adenohypophysis, CTNNB1 gene, and microRNAs might be implicated in the craniopharyngioma pathogenesis. The objective of this study is to perform the molecular analysis of HESX1, PROP1, POU1F1, and CTNNB1 genes and evaluate a panel of miRNA expression in craniopharyngioma. We also verified whether the presence of CTNNB1 mutation is associated with clinical findings...
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