Article
Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma.
Acta neuropathologica - 1 Aug 2012
Andoniadou Cynthia L, Gaston-Massuet Carles, Reddy Rukmini, Schneider Ralph P, Blasco Maria A, Le Tissier Paul, Jacques Thomas S, Pevny Larysa H, Dattani Mehul T, Martinez-Barbera Juan Pedro
Abstract excerpt
Activating mutations in the gene encoding β-catenin have been identified in the paediatric form of human craniopharyngioma (adamantinomatous craniopharyngioma, ACP), a histologically benign but aggressive pituitary tumour accounting for up to 10% of paediatric intracranial tumours. Recently, we generated an ACP mouse model and revealed that, as in human ACP, nucleocytoplasmic accumulation of β-catenin (β-cat(nc))...
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