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Article

Why are translationally sub-optimal synonymous codons used in Escherichia coli?

Journal of molecular evolution - 1 Sept 2001

Smith N G, Eyre-Walker A

Abstract excerpt

Natural selection favors certain synonymous codons which aid translation in Escherichia coli, yet codons not favored by translational selection persist. We use the frequency distributions of synonymous polymorphisms to test three hypotheses for the existence of translationally sub-optimal codons: (1) selection is a relatively weak force, so there is a balance between mutation, selection, and drift; (2) at some...

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Identifiers

PMID: 11523009
DOI: 10.1007/s002390010212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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