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Article

Heterogeneous inducible mammary-specific expression of Jab/SOCS1 in lactating transgenic mice is associated with no obvious phenotype, even at the cellular level.

Transgenic research - 1 Dec 2003

Petridou Barbara, Soulier Solange, Besnard Nathalie, Hudrisier Marthe, Hue-Beauvais Catherine, Costa Da Silva José, Djiane Jean, Vilotte Jean-Luc

Abstract excerpt

The cytokine-inducible suppressor of cytokine signalling SOCS1, or JAB, has been shown to be implicated in vitro in the negative regulation of the prolactin-receptor-induced activation of JAK2 and STAT5. Disruption of this gene in vivo resulted in an accelerated mammary gland development. In the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14713198
DOI: 10.1023/b:trag.0000005165.85843.2e

Genes

SOCS1
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14713198-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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