The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.

doi:10.1074/jbc.C200608200

Article

The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.

The Journal of biological chemistry - 24 Jan 2003

Sasaki Atsuo, Inagaki-Ohara Kyoko, Yoshida Takafumi, Yamanaka Atsushi, Sasaki Mika, Yasukawa Hideo, Koromilas Antonis E, Yoshimura Akihiko

Abstract excerpt

The suppressor of cytokine signaling-3 (SOCS3/CIS-33/SSI-3) is an important negative regulator of cytokine signaling. Here, we show that an N-terminal truncated isoform (DeltaN-SOCS3) translated from the internal AUG codon 12 was profoundly induced by endoplasmic reticulum (ER) stress- or active double-stranded RNA-activated protein kinase PKR, as a result of induction of eukaryotic initiation factor 2alpha...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.

Abstract excerpt

Topics

Related research