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Article

Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression.

Journal of virology - 1 Jan 2000

Barnabas S, Andrisani O M

Abstract excerpt

The hepatitis B virus X protein (pX) interacts directly with the bZip transactivator CREB and the bZip repressors ICERIIgamma and ATF3, increasing their DNA-binding affinity in vitro and their transcriptional efficacy in vivo. However, the mechanism of bZip-pX interaction and of the pX-mediated increase in the bZip transcriptional efficacy remains to be understood. In this study with deletion mutants of pX, we...

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Share to Basic-Leucine Zipper Transcription Factors
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10590094
DOI: 10.1128/jvi.74.1.83-90.2000
PMCID: PMC111516

Genes

ATF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression.PMID 10590094Read ↗

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein InteractionsSemantic proximity Read ↗

The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review).Semantic proximity Read ↗

An internal segment (residues 58-119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver.Semantic proximity Read ↗

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors.Semantic proximity Read ↗

Hepatitis B Virus X Protein: Structure, Function and BiologySemantic proximity Read ↗

pX, the HBV‐encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF‐independent manner.Semantic proximity Read ↗

UVDDB p127-binding modulates activities and intracellular distribution of hepatitis B virus X protein.Semantic proximity Read ↗

pX, the HBV-encoded coactivator, suppresses the phenotypes of TBP and TAFII250 mutants.Semantic proximity Read ↗

Transactivating function and expression of the x gene of hepatitis B virus.Semantic proximity Read ↗

The hepatitis B virus X gene induces p53-mediated programmed cell deathSemantic proximity Read ↗

HBx enhances CPAP expression via interacting with CREB to promote hepatocarcinogenesis in HBV-associated HCCSemantic proximity Read ↗

Hepatitis B Viral X Protein Overcomes Inhibition of E2F1 Activity by pRb on the Human <i>Rb</i> Gene PromoterSemantic proximity Read ↗

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